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Secretion of extracellular vesicles is a general cellular activity that spans the range from simple unicellular organisms (e.g. archaea; Gram‐positive and Gram‐negative bacteria) to complex multicellular ones, suggesting that this extracellular vesicle‐mediated communication is evolutionarily conserved. Extracellular vesicles are spherical bilayered proteolipids with a mean diameter of 20–1,000 nm, which are known to contain various bioactive molecules including proteins, lipids, and nucleic acids. Here, we present EVpedia, which is an integrated database of high‐throughput datasets from prokaryotic and eukaryotic extracellular vesicles. EVpedia provides high‐throughput datasets of vesicular components (proteins, mRNAs, miRNAs, and lipids) present on prokaryotic, non‐mammalian eukaryotic, and mammalian extracellular vesicles. In addition, EVpedia also provides an array of tools, such as the search and …