作者
Cecilia Lässer, Maria Eldh, Jan Lötvall
发表日期
2012/1/9
期刊
JoVE (Journal of Visualized Experiments)
期号
59
页码范围
e3037
简介
The field of exosome research is rapidly expanding, with a dramatic increase in publications in recent years. These small vesicles (30-100 nm) of endocytic origin were first proposed to function as a way for reticulocytes to eradicate the transferrin receptor while maturing into erythrocytes1, and were later named exosomes. Exosomes are formed by inward budding of late endosomes, producing multivesicular bodies (MVBs), and are released into the environment by fusion of the MVBs with the plasma membrane2. Since the first discovery of exosomes, a wide range of cells have been shown to release these vesicles. Exosomes have also been detected in several biological fluids, including plasma, nasal lavage fluid, saliva and breast milk3-6. Furthermore, it has been demonstrated that the content and function of exosomes depends on the originating cell and the conditions under which they are produced. A variety of …
引用总数
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学术搜索中的文章
C Lässer, M Eldh, J Lötvall - JoVE (Journal of Visualized Experiments), 2012