作者
Cumali Efe, Murat Torgutalp, Ida Henriksson, Fatema Alalkim, Ellina Lytvyak, Hirsh Trivedi, Fatih Eren, Janett Fischer, Maneerat Chayanupatkul, Claudia Coppo, Tugrul Purnak, Luigi Muratori, Mårten Werner, Paolo Muratori, Fredrik Rorsman, Kristina Onnerhag, Emma Nilsson, Alexandra Heurgué‐Berlot, Nurhan Demir, David Semela, Murat Kıyıcı, Thomas D Schiano, Aldo J Montano‐Loza, Thomas Berg, Ersan Ozaslan, Eric M Yoshida, Alan Bonder, Hanns‐Ulrich Marschall, Benedetta Terziroli Beretta‐Piccoli, Staffan Wahlin
发表日期
2021/4
期刊
Journal of gastroenterology and hepatology
卷号
36
期号
4
页码范围
936-942
简介
Background and Aim
The prevalence and clinical significance of extrahepatic autoimmune diseases (EHAIDs) have not been evaluated in a large cohort of primary biliary cholangitis (PBC).
Methods
The medical records of 1554 patients with PBC from 20 international centers were retrospectively reviewed. Development of decompensated cirrhosis (ascites, variceal bleeding, and/or hepatic encephalopathy) and hepatocellular carcinoma were considered clinical endpoints.
Results
A total of 35 different EHAIDs were diagnosed in 440 (28.3%) patients with PBC. Patients with EHAIDs were more often female (92.5% vs 86.1%, P < 0.001) and seropositive for anti‐mitochondrial antibodies (88% vs 84%, P = 0.05) and antinuclear antibodies and/or smooth muscle antibodies (53.8% vs 43.6%, P = 0.005). At presentation, patients with EHAIDs had significantly lower levels of alkaline phosphatase (1.76 vs 1.98 × upper …
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C Efe, M Torgutalp, I Henriksson, F Alalkim, E Lytvyak… - Journal of gastroenterology and hepatology, 2021