作者
Ann Olsson, Neela Guha, Liacine Bouaoun, Hans Kromhout, Susan Peters, Jack Siemiatycki, Vikki Ho, Per Gustavsson, Paolo Boffetta, Roel Vermeulen, Thomas Behrens, Thomas Brüning, Benjamin Kendzia, Pascal Guénel, Danièle Luce, Stefan Karrasch, Heinz-Erich Wichmann, Dario Consonni, Maria Teresa Landi, Neil E Caporaso, Franco Merletti, Dario Mirabelli, Lorenzo Richiardi, Karl-Heinz Jöckel, Wolfgang Ahrens, Hermann Pohlabeln, Adonina Tardon, David Zaridze, John K Field, Jolanta Lissowska, Beata Świątkowska, John R McLaughlin, Paul A Demers, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Tamás Pándics, Eleonora Fabianova, Dana Mates, Francesco Forastiere, Bas Bueno-de-Mesquita, Joachim Schüz, Kurt Straif
发表日期
2022/7/1
期刊
Cancer Epidemiology, Biomarkers & Prevention
卷号
31
期号
7
页码范围
1433-1441
出版商
American Association for Cancer Research
简介
Background
Exposure to polycyclic aromatic hydrocarbons (PAH) occurs widely in occupational settings. We investigated the association between occupational exposure to PAH and lung cancer risk and joint effects with smoking within the SYNERGY project.
Methods
We pooled 14 case–control studies with information on lifetime occupational and smoking histories conducted between 1985 and 2010 in Europe and Canada. Exposure to benzo[a]pyrene (BaP) was used as a proxy of PAH and estimated from a quantitative general population job-exposure matrix. Multivariable unconditional logistic regression models, adjusted for smoking and exposure to other occupational lung carcinogens, estimated ORs, and 95% confidence intervals (CI).
Results
We included 16,901 lung cancer cases and 20,965 frequency-matched controls. Adjusted OR for PAH …
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A Olsson, N Guha, L Bouaoun, H Kromhout, S Peters… - Cancer Epidemiology, Biomarkers & Prevention, 2022