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Styrene is a high production volume chemical primarily used to produce polystyrene polymers and it is found in workplace air in the reinforced plastics industry. Styrene is also present in tobacco smoke, and in air pollution. In March 2018, a Working Group of leading scientists from 24 countries met at the International Agency for Research on Cancer (IARC) in Lyon, France, to re-evaluate the carcinogenicity of styrene (in addition to styrene-7,8-oxide and quinolone, not addressed here), based on published human, animal and mechanistic data. The most informative epidemiological studies were occupational cohort studies conducted in different countries in the reinforced plastics industry, suggesting that exposure to styrene causes lymphohaematopoietic malignancies, with higher consistency in the evidence for leukaemias and in particular myeloid leukaemia. However, confounding by other co-occurring …