作者
Sian Taylor-Phillips, Karoline Freeman, Julia Geppert, Adeola Agbebiyi, Olalekan A Uthman, Jason Madan, Angus Clarke, Siobhan Quenby, Aileen Clarke
发表日期
2016/1/1
来源
BMJ open
卷号
6
期号
1
页码范围
e010002
出版商
British Medical Journal Publishing Group
简介
Objective
To measure test accuracy of non-invasive prenatal testing (NIPT) for Down, Edwards and Patau syndromes using cell-free fetal DNA and identify factors affecting accuracy.
Design
Systematic review and meta-analysis of published studies.
Data sources
PubMed, Ovid Medline, Ovid Embase and the Cochrane Library published from 1997 to 9 February 2015, followed by weekly autoalerts until 1 April 2015.
Eligibility criteria for selecting studies
English language journal articles describing case–control studies with ≥15 trisomy cases or cohort studies with ≥50 pregnant women who had been given NIPT and a reference standard.
Results
41, 37 and 30 studies of 2012 publications retrieved were included in the review for Down, Edwards and Patau syndromes. Quality appraisal identified high risk of bias in included studies, funnel plots showed evidence of publication bias. Pooled sensitivity was 99.3% (95% CI …
学术搜索中的文章
S Taylor-Phillips, K Freeman, J Geppert, A Agbebiyi… - BMJ open, 2016