作者
Katy L Cooper, Jason Madan, Sophie Whyte, Matt D Stevenson, Ron L Akehurst
发表日期
2011/12
来源
BMC cancer
卷号
11
页码范围
1-11
出版商
BioMed Central
简介
Background
Febrile neutropenia (FN) occurs following myelosuppressive chemotherapy and is associated with morbidity, mortality, costs, and chemotherapy reductions and delays. Granulocyte colony-stimulating factors (G-CSFs) stimulate neutrophil production and may reduce FN incidence when given prophylactically following chemotherapy.
Methods
A systematic review and meta-analysis assessed the effectiveness of G-CSFs (pegfilgrastim, filgrastim or lenograstim) in reducing FN incidence in adults undergoing chemotherapy for solid tumours or lymphoma. G-CSFs were compared with no primary G-CSF prophylaxis and with one another. Nine databases were searched in December 2009. Meta-analysis used a random effects model due to heterogeneity.
Results
Twenty studies compared primary G-CSF …
引用总数
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