作者
Matthew L Costa, Juul Achten, Ruth Knight, Julie Bruce, Susan J Dutton, Jason Madan, Melina Dritsaki, Nick Parsons, Miguel Fernandez, Richard Grant, Jagdeep Nanchahal, Peter Hull, Simon Scott, David Melling, Javed Salim, Hemant Sharma, William Eardley, Peter V Giannoudis, Jitendra Mangwani, Andrew Riddick, Paul Harnett, Edward Mills, Mike R Reed, Ben J Ollivere, Xavier L Griffin, Mark D Brinsden, Ravichandran Karthikeyan, Benedict A Rogers, Peter Bates, Haroon Majeed, Damian McClelland, Sharad Bhatnagar, Caroline B Hing, Rajarshi Bhattacharya, Usman Butt, George Cox, Khitish Mohanty, Mateen Arastu, Paul Harwood, Alex L Sims, Brett Rocos, Ian Baxter, Tanvir Khan, Paul M Guyver, Siddhant Kapoor, Michalis Kaminaris, Edward Massa, Richard Unsworth, Robert Jordan, Tarek Boutefnouchet, Laura Beddard, Graham Lawton, WHIST Trial Collaborators
发表日期
2020/2/11
期刊
Jama
卷号
323
期号
6
页码范围
519-526
出版商
American Medical Association
简介
Importance
Following surgery to treat major trauma–related fractures, deep wound infection rates are high. It is not known if negative pressure wound therapy can reduce infection rates in this setting.
Objective
To assess outcomes in patients who have incisions resulting from surgery for lower limb fractures related to major trauma and were treated with either incisional negative pressure wound therapy or standard wound dressing.
Design, Setting, and Participants
A randomized clinical trial conducted at 24 trauma hospitals representing the UK Major Trauma Network that included 1548 patients aged 16 years or older who underwent surgery for a lower limb fracture caused by major trauma from July 7, 2016, through April 17, 2018, with follow-up to December 11, 2018.
Interventions
Incisional negative pressure wound therapy (n = 785), which involved a specialized dressing used to create negative pressure over the …
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ML Costa, J Achten, R Knight, J Bruce, SJ Dutton… - Jama, 2020