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Statins have been shown to significantly reduce morbidity and mortality in patients with coronary artery disease (CAD), and also in patients with dyslipidaemia when statins are taken regularly. Middle‐aged patients have the highest level of forecasting benefit and little is known about persistence rate of these therapies in a real‐life setting. The objective was to evaluate the persistence rate of middle‐aged patients initiating a statin therapy and its relation with several determinants for primary and secondary prevention.

A cohort was reconstructed using the RAMQ databases. All patients aged 50–64 years‐old who received at least one statin prescription between 1 January, 1998 and 31 December, 2000 for a new intention of treatment for dyslipidaemia were included in the cohort and followed up until 30 June, 2001. The date of the first prescription of statin was defined as the index date. There were …