作者
Hong-Guang Xie, Victor Dishy, Gbenga Sofowora, Richard B Kim, Ruth Landau, Richard M Smiley, Hong-Hao Zhou, Alastair JJ Wood, Paul Harris, C Michael Stein
发表日期
2001/4/1
期刊
Pharmacogenetics and Genomics
卷号
11
期号
3
页码范围
191-197
出版商
LWW
简介
There are marked interethnic differences in β 1-adrenoceptor-mediated responsiveness, with sensitivity decreased in African-Americans and increased in Chinese compared with Caucasians. Therefore, the frequency of a common naturally occurring polymorphism of the human β 1-adrenoceptor gene (Arg 389 Gly), which has functional importance in vitro, was determined in 194 African-Americans, 316 Caucasian-Americans, 221 Hispanic-Americans and 142 Chinese. African-Americans were found to have a significantly lower frequency of the Arg 389 allele than the other three ethnic groups (all P< 0.01). In the populations studied, the order of the distribution of the Arg 389 allele was: Chinese (74%)> Caucasians (72%)> Hispanics (67%)> African-Americans (58%). To determine the functional significance of the Arg 389 Gly β 1-adrenoceptor polymorphism, in-vivo heart rate responses to exercise were compared …
引用总数
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HG Xie, V Dishy, G Sofowora, RB Kim, R Landau… - Pharmacogenetics and Genomics, 2001