作者
Alex T Sia, Yvonne Lim, Eileen CP Lim, Rachelle WC Goh, Hai Yang Law, Ruth Landau, Yik-ying Teo, Ene Choo Tan
发表日期
2008/9/1
期刊
The Journal of the American Society of Anesthesiologists
卷号
109
期号
3
页码范围
520-526
出版商
The American Society of Anesthesiologists
简介
Background
Previous studies have shown that genetic variability at position 118 of the human mu-opioid receptor gene altered patients' response to intravenous morphine. The purpose of this study was to investigate whether this polymorphism contributes to the variability in response to morphine for postcesarean analgesia.
Methods
After investigators obtained informed consent, 588 healthy women received 0.1 mg intrathecal morphine for postcesarean analgesia. Their blood samples were genotyped for the A118G polymorphism-A118 homozygous (AA), heterozygous (AG), or homozygous for the G allele (GG). Pain scores, the severity of nausea and vomiting, the incidence of pruritus, and the total self-administered intravenous morphine were recorded for the first 24 postoperative hours.
Results
Two hundred seventy women (46%) were AA, 234 (40%) were …
引用总数
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