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Glucagon‐like peptide 1 (GLP‐1) and glucagon share the same precursor molecule proglucagon, but each arises from a distinct posttranslational process in a tissue‐specific manner. Recently, it has been shown that GLP‐1 is co‐expressed with glucagon in pancreatic islet cells. This study was aimed to investigate the progressive changes of GLP‐1 versus glucagon production in pancreatic islets during the course of diabetes development.

Both type 1 (non‐obese diabetes mice) and type 2 (db/db mice) diabetes models were employed in this study. The mice were monitored closely for their diabetes progression and were sacrificed at different stages according to their blood glucose levels. GLP‐1 and glucagon expression in the pancreatic islets was examined using immunohistochemistry assays. Quantitative analysis was performed to evaluate the significance of the changes.

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