作者
Ghobad Mohammadi, Amineh Shakeri, Ali Fattahi, Pardis Mohammadi, Ali Mikaeili, Alireza Aliabadi, Khosro Adibkia
发表日期
2017/2
期刊
Pharmaceutical research
卷号
34
页码范围
301-309
出版商
Springer US
简介
Purpose
Nystatin loaded PLGA and PLGA-Glucosamine nanoparticles were formulated. PLGA were functionalized with Glucosamine (PLGA-GlcN) to enhance the adhesion of nanoparticles to Candida Albicans (C.albicans) cell walls.
Method
Quasi-emulsion solvent diffusion method was employed using PLGA and PLGA-GlcN with various drug–polymer ratios for the preparation of nanoparticles. The nanoparticles were evaluated for size, zeta potential, polydispersity index, drug crystallinity, loading efficiency and release properties. DSC, SEM, XRPD, 1H-NMR, and FT-IR were performed to analyze the physicochemical properties of the nanoparticles. Antifungal activity of the nanoparticles was evaluated by determination of MICs against C.albicans.
Results
The spectra of 1H-NMR and FT-IR analysis ensured GlcN …
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G Mohammadi, A Shakeri, A Fattahi, P Mohammadi… - Pharmaceutical research, 2017