作者
Noham Wolpe, James W Moore, Charlotte L Rae, Timothy Rittman, Ellemarije Altena, Patrick Haggard, James B Rowe
发表日期
2014/1/1
期刊
Brain
卷号
137
期号
1
页码范围
208-220
出版商
Oxford University Press
简介
The volitional impairments of alien limb and apraxia are a defining feature of the corticobasal syndrome, but a limited understanding of their neurocognitive aetiology has hampered progress towards effective treatments. Here we combined several key methods to investigate the mechanism of impairments in voluntary action in corticobasal syndrome. We used a quantitative measure of awareness of action that is based on well-defined processes of motor control; structural and functional anatomical information; and evaluation against the clinical volitional disorders of corticobasal syndrome. In patients and healthy adults we measured ‘intentional binding’, the perceived temporal attraction between voluntary actions and their sensory effects. Patients showed increased binding of the perceived time of actions towards their effects. This increase correlated with the severity of alien limb and apraxia, which we suggest …
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