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The role of artificial sweeteners in body-weight regulation is still unclear.

We investigated the effect of long-term supplementation with drinks and foods containing either sucrose or artificial sweeteners on ad libitum food intake and body weight in overweight subjects.

For 10 wk, overweight men and women consumed daily supplements of either sucrose [n = 21, body mass index (BMI; in kg/m²) = 28.0] or artificial sweeteners (n = 20, BMI = 27.6). On average, sucrose supplements provided 3.4 MJ and 152 g sucrose/d and sweetener supplements provided 1.0 MJ and 0 g sucrose/d.

After 10 wk, the sucrose group had increases in total energy (by 1.6 MJ/d), sucrose (to 28% of energy), and carbohydrate intakes and decreases in fat and protein intakes. The sweetener group had small but significant decreases in sucrose intake and energy density. Body weight and fat mass increased in …