作者
Jean-François Rouland, Carlo Enrico Traverso, Ingeborg Stalmans, Lamia El Fekih, Laurent Delval, Didier Renault, Christophe Baudouin
发表日期
2013/2/1
期刊
British journal of ophthalmology
卷号
97
期号
2
页码范围
196-200
出版商
BMJ Publishing Group Ltd
简介
Aim
To compare efficacy (intraocular pressure (IOP) reduction) and safety of preservative-free latanoprost (T2345) to benzalkonium chloride (BAK)-preserved latanoprost (BPL; Xalatan) in ocular hypertension (OHT) or primary open angle glaucoma (POAG) patients.
Methods
Prospective, international, multicentre, randomised, investigator-masked, parallel–group trial. After a wash-out period, POAG or OHT patients, previously managed by BPL monotherapy, randomly received T2345 or BPL (one drop into the affected eye(s)) once daily from D0 to D84. Change in IOP was measured at 09:00 (±1 h) from D0 to D84 in the worse eye.
Results
Mean IOP reduction (D0–D84) was −8.6±2.6 mm Hg (−36%) on T2345 and −9.0±2.4 mm Hg (−38%) on BPL, confirming non-inferiority of T2345 to BPL. Non-inferiority of T2345 was observed from D15. The most frequent ocular adverse event, drug intolerance, was reported …
学术搜索中的文章
JF Rouland, CE Traverso, I Stalmans, L El Fekih… - British journal of ophthalmology, 2013