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To examine differences in the frequency and severity of federally reported adverse events between caffeine-containing and non–caffeine-containing products while also identifying the category of caffeine-containing products associated with the highest frequency and severity of adverse events.

All adverse event reports that met specified eligibility criteria and were submitted to the Center for Food Safety and Applied Nutrition Adverse Event Reporting System between January 1, 2014, and June 29, 2018, were extracted. In this retrospective observational study, the most severe adverse event experienced, an ordinal variable, was categorized into death, life-threatening, hospitalization/disability, and emergency department visit. A nonproportional odds model was used to compare the odds of caffeine-containing products being associated with more severe adverse events relative to a …