作者
Peter Koopman, John Gubbay, Nigel Vivian, Peter Goodfellow, Robin Lovell-Badge
发表日期
1991/5/9
期刊
Nature
卷号
351
期号
6322
页码范围
117-121
出版商
Nature Publishing Group UK
简介
The initiation of male development in mammals requires one or more genes on the Y chromosome. A recently isolated gene, termed SRY in humans and Sry in mouse, has many of the genetic and biological properties expected of a Y-located testis-determining gene. It is now shown that Sry on a 14-kilobase genomic DNA fragment is sufficient to induce testis differentiation and subsequent male development when introduced into chromosomally female mouse embryos.
引用总数
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P Koopman, J Gubbay, N Vivian, P Goodfellow… - Nature, 1991