作者
Carolyn Weber, Maximilian Luehr, Georgi Petrov, Martin Misfeld, Payam Akhyari, Sems-Malte Tugtekin, Mahmoud Diab, Shekhar Saha, Ahmed Elderia, Artur Lichtenberg, Christian Hagl, Torsten Doenst, Klaus Matschke, Michael A Borger, Thorsten Wahlers
发表日期
2022/10/1
期刊
The Annals of Thoracic Surgery
卷号
114
期号
4
页码范围
1349-1356
出版商
Elsevier
简介
Background
In 2009, updated European Society of Cardiology guidelines on the prevention, diagnosis, and treatment of infective endocarditis (IE) were released and restricted the use of antibiotic prophylaxis to high-risk patients only. The aim of this study was to analyze the effect of the restrictive antibiotic regimen on the incidence and manifestations of surgically treated IE before and after the guideline change.
Methods
This study retrospectively analyzed data of 4917 patients who underwent valve surgical procedures for IE between 1994 and 2018 in 6 German cardiac surgery centers. Potential risk factors for 30-day mortality were assessed using logistic regression. Interrupted time series regression was used to evaluate the effect of the guideline change on the manifestation of IE.
Results
A total of 2014 patients (41%) underwent surgical procedures before the guideline change, and 2903 patients (59%) underwent …
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C Weber, M Luehr, G Petrov, M Misfeld, P Akhyari… - The Annals of Thoracic Surgery, 2022