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The medicinal properties of some endemic and indigenous plants from the ancestral domain of the Aytas, a group of indigenous people of Kanawan, Morong, Bataan Province, Philippines were investigated. One focus of the study was anticancer property. Crude ethanolic extracts of leaves were evaluated for cytotoxicity against two human cancer cell lines: lung non-small cell adenocarcinoma (A549) and colon carcinoma (HCT 116). Cytotoxicity was determined using an assay for the reduction of the yellow tetrazolium (MTT) into purple formazan. Among the 15 plant species tested, crude extracts of Aglaia loheri Blanco (Meliaceae), Ficus septica Burm. (Moraceae) and Voacanga globosa (Blanco) Merr. (Apocynaceae) exhibited high toxicity against the two cell lines with IC₅₀ values below 20 ì g/mL. These extracts were subsequently partitioned into ethyl acetate and hexane fractions and tested again for …