作者
Matthew Traylor, Martin Farrall, Elizabeth G Holliday, Cathie Sudlow, Jemma C Hopewell, Yu-Ching Cheng, Myriam Fornage, M Arfan Ikram, Rainer Malik, Steve Bevan, Unnur Thorsteinsdottir, Mike A Nalls, WT Longstreth, Kerri L Wiggins, Sunaina Yadav, Eugenio A Parati, Anita L DeStefano, Bradford B Worrall, Steven J Kittner, Muhammad Saleem Khan, Alex P Reiner, Anna Helgadottir, Sefanja Achterberg, Israel Fernandez-Cadenas, Sherine Abboud, Reinhold Schmidt, Matthew Walters, Wei-Min Chen, E Bernd Ringelstein, Martin O'Donnell, Weang Kee Ho, Joanna Pera, Robin Lemmens, Bo Norrving, Peter Higgins, Marianne Benn, Michele Sale, Gregor Kuhlenbäumer, Alexander SF Doney, Astrid M Vicente, Hossein Delavaran, Ale Algra, Gail Davies, Sofia A Oliveira, Colin NA Palmer, Ian Deary, Helena Schmidt, Massimo Pandolfo, Joan Montaner, Cara Carty, Paul IW de Bakker, Konstantinos Kostulas, Jose M Ferro, Natalie R van Zuydam, Einar Valdimarsson, Børge G Nordestgaard, Arne Lindgren, Vincent Thijs, Agnieszka Slowik, Danish Saleheen, Guillaume Paré, Klaus Berger, Gudmar Thorleifsson, Albert Hofman, Thomas H Mosley, Braxton D Mitchell, Karen Furie, Robert Clarke, Christopher Levi, Sudha Seshadri, Andreas Gschwendtner, Giorgio B Boncoraglio, Pankaj Sharma, Joshua C Bis, Solveig Gretarsdottir, Bruce M Psaty, Peter M Rothwell, Jonathan Rosand, James F Meschia, Kari Stefansson, Martin Dichgans, Hugh S Markus, Australian Stroke Genetics Collaborative, Wellcome Trust Case Control Consortium 2 (WTCCC2, International Stroke Genetics Consortium
发表日期
2012/11/30
期刊
The Lancet Neurology
卷号
11
期号
11
页码范围
951-962
出版商
Elsevier
简介
Background
Various genome-wide association studies (GWAS) have been done in ischaemic stroke, identifying a few loci associated with the disease, but sample sizes have been 3500 cases or less. We established the METASTROKE collaboration with the aim of validating associations from previous GWAS and identifying novel genetic associations through meta-analysis of GWAS datasets for ischaemic stroke and its subtypes.
Methods
We meta-analysed data from 15 ischaemic stroke cohorts with a total of 12 389 individuals with ischaemic stroke and 62 004 controls, all of European ancestry. For the associations reaching genome-wide significance in METASTROKE, we did a further analysis, conditioning on the lead single nucleotide polymorphism in every associated region. Replication of novel suggestive signals was done in 13 347 cases and 29 083 controls.
Findings
We verified previous associations for …
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