作者
Stuart J Connolly, A John Camm, Jonathan L Halperin, Campbell Joyner, Marco Alings, John Amerena, Dan Atar, Álvaro Avezum, Per Blomström, Martin Borggrefe, Andrzej Budaj, Shih-Ann Chen, Chi Keong Ching, Patrick Commerford, Antonio Dans, Jean-Marc Davy, Etienne Delacrétaz, Giuseppe Di Pasquale, Rafael Diaz, Paul Dorian, Greg Flaker, Sergey Golitsyn, Antonio Gonzalez-Hermosillo, Christopher B Granger, Hein Heidbüchel, Josef Kautzner, June Soo Kim, Fernando Lanas, Basil S Lewis, Jose L Merino, Carlos Morillo, Jan Murin, Calambur Narasimhan, Ernesto Paolasso, Alexander Parkhomenko, Nicholas S Peters, Kui-Hian Sim, Martin K Stiles, Supachai Tanomsup, Lauri Toivonen, János Tomcsányi, Christian Torp-Pedersen, Hung-Fat Tse, Panos Vardas, Dragos Vinereanu, Denis Xavier, Jun Zhu, Jun-Ren Zhu, Lydie Baret-Cormel, Estelle Weinling, Christoph Staiger, Salim Yusuf, Susan Chrolavicius, Rizwan Afzal, Stefan H Hohnloser
发表日期
2011/12/15
期刊
New England Journal of Medicine
卷号
365
期号
24
页码范围
2268-2276
出版商
Massachusetts Medical Society
简介
Background
Dronedarone restores sinus rhythm and reduces hospitalization or death in intermittent atrial fibrillation. It also lowers heart rate and blood pressure and has antiadrenergic and potential ventricular antiarrhythmic effects. We hypothesized that dronedarone would reduce major vascular events in high-risk permanent atrial fibrillation.
Methods
We assigned patients who were at least 65 years of age with at least a 6-month history of permanent atrial fibrillation and risk factors for major vascular events to receive dronedarone or placebo. The first coprimary outcome was stroke, myocardial infarction, systemic embolism, or death from cardiovascular causes. The second coprimary outcome was unplanned hospitalization for a cardiovascular cause or death.
Results
After the enrollment of 3236 patients, the study was stopped for safety reasons. The first coprimary outcome occurred in 43 patients receiving …
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SJ Connolly, AJ Camm, JL Halperin, C Joyner… - New England Journal of Medicine, 2011