作者
Christopher C Butler, Alike W van Der Velden, Emily Bongard, Benjamin R Saville, Jane Holmes, Samuel Coenen, Johanna Cook, Nick A Francis, Roger J Lewis, Maciek Godycki-Cwirko, Carl Llor, Sławomir Chlabicz, Christos Lionis, Bohumil Seifert, Pär-Daniel Sundvall, Annelies Colliers, Rune Aabenhus, Lars Bjerrum, Nicolay Jonassen Harbin, Morten Lindbæk, Dominik Glinz, Heiner C Bucher, Bernadett Kovács, Ruta Radzeviciene Jurgute, Pia Touboul Lundgren, Paul Little, Andrew W Murphy, An De Sutter, Peter Openshaw, Menno D de Jong, Jason T Connor, Veerle Matheeussen, Margareta Ieven, Herman Goossens, Theo J Verheij
发表日期
2020/1/4
期刊
The Lancet
卷号
395
期号
10217
页码范围
42-52
出版商
Elsevier
简介
Background
Antivirals are infrequently prescribed in European primary care for influenza-like illness, mostly because of perceived ineffectiveness in real world primary care and because individuals who will especially benefit have not been identified in independent trials. We aimed to determine whether adding antiviral treatment to usual primary care for patients with influenza-like illness reduces time to recovery overall and in key subgroups.
Methods
We did an open-label, pragmatic, adaptive, randomised controlled trial of adding oseltamivir to usual care in patients aged 1 year and older presenting with influenza-like illness in primary care. The primary endpoint was time to recovery, defined as return to usual activities, with fever, headache, and muscle ache minor or absent. The trial was designed and powered to assess oseltamivir benefit overall and in 36 prespecified subgroups defined by age, comorbidity …
学术搜索中的文章
CC Butler, AW van Der Velden, E Bongard, BR Saville… - The Lancet, 2020