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We present a review of statistical inference in generalized linear mixed models (GLMMs). GLMMs are an extension of generalized linear models and are suitable for the analysis of non‐normal data with a clustered structure. A GLMM contains parameters common to all clusters (fixed regression effects and variance components) and cluster‐specific parameters. The latter parameters are assumed to be randomly drawn from a population distribution. The parameters of this population distribution (the variance components) have to be estimated together with the fixed effects. We focus on the case in which the cluster‐specific parameters are normally distributed. The cluster‐specific effects are integrated out of the likelihood so that the fixed effects and variance components can be estimated. Unfortunately, the integral over the cluster‐specific effects is intractable for most GLMMs with a normal mixing distribution. Within a …