作者
Aldo Henrique Tavares, Larissa Fernandes, Anamélia Lorenzetti Bocca, Ildinete Silva-Pereira, Maria Sueli Felipe
发表日期
2015/8/1
来源
Fungal Genetics and Biology
卷号
81
页码范围
98-109
出版商
Academic Press
简介
The thermodimorphic fungi Paracoccidioides brasiliensis and Paracoccidioides lutzii are the etiologic agents of Paracoccidioidomycosis (PCM), the most important endemic systemic mycosis in Latin America. Paracoccidioides grows as saprophytic mycelia that produce infective conidia propagules, which are inhaled into the lungs where the fungus converts to the pathogenic yeast form. From the lungs, Paracoccidioides may disseminate through blood and lymphatics to several other organs and tissues. During the last decade we have witnessed the generation of a large amount of transcriptomic data regarding the events leading to the morphological transition and host niche adaptation. In this review we summarize those findings and discuss the consequence of gene expression plasticity in the persistence and survival of this pathogen. In addition, we discuss the future trends on the host–pathogen studies and how …
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AH Tavares, L Fernandes, AL Bocca, I Silva-Pereira… - Fungal Genetics and Biology, 2015