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The vasodilator effect of the ethanolic extract of leaves from Hancornia speciosa Gomes (HSE) was studied in rat aortic rings. HSE produced a concentration-dependent vasodilatation (pIC₅₀=5.6±0.1), which was completely abolished in endothelium-denuded vessels. The endothelium-dependent vasodilatation induced by HSE was abolished by l-NAME (100μM), a nitric oxide (NO) synthase inhibitor, but not atropine (1μM; pIC₅₀=5.6±0.2), a muscarinic receptor antagonist, nor indomethacin (10μM; pIC₅₀=5.4±0.2), a cyclooxygenase inhibitor. The concentration–response curve of HSE was significantly shifted to the left by superoxide dismutase (SOD; 300U/mL). In addition, while SOD displaced the 3-morpholino-sidnonimine (SIN-1; P<0.05) concentration–effect curve to the left, HSE (50μg/mL) had no effect. Finally, wortmannin (0.3μM), an inhibitor of phosphatidyl-inositol 3-kinase (PI3K), dramatically reduced the …