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We have recently described, in the mouse aorta, the vasodilator effect of angiotensin-(1–7) (Ang-(1–7)) was mediated by activation of the Mas Ang-(1–7) receptor and that A-779 and D-Pro⁷-Ang-(1–7) act as Mas receptor antagonists. In this work we show pharmacological evidence for the existence of a different Ang-(1–7) receptor subtype mediating the vasodilator effect of Ang-(1–7) in the aorta from Sprague–Dawley (SD) rats. Ang-(1–7) induced an endothelium-dependent vasodilator effect in aortic rings from SD rats which was inhibited by removal of the endothelium and by l-NAME (100μM) but not by indomethacin (10μM). The Ang-(1–7) receptor antagonist D-Pro⁷-Ang-(1–7) (0.1μM) abolished the vasodilator effect of the peptide. However, the other specific Ang-(1–7) receptor antagonist, A-779 in concentrations up to 10μM, did not affect vasodilation induced by Ang-(1–7). The Ang II AT₁ and AT₂ receptors …