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Research has consistently shown that regular physical activity may protect against the development and maintenance of depression and anxiety, whereas sedentary behavior may exacerbate depression and anxiety. However, much of the past research in this area has focused on non-clinical populations. Therefore, the goal of this study was to examine the relations of physical activity and sedentary behavior to depression and anxiety symptom severity among an understudied patient population, patients in residential substance use disorder (SUD) treatment. This study also sought to determine the extent to which physical activity and sedentary behavior relate to depression and anxiety symptom severity above and beyond an established transdiagnostic risk factor for depression and anxiety, emotion dysregulation. A sample of 41 patients from a residential SUD treatment facility completed a variety of self-report …