作者
Peter Schuster, Walter Fontana, Peter F Stadler, Ivo L Hofacker
发表日期
1994/3/22
期刊
Proceedings of the Royal Society of London. Series B: Biological Sciences
卷号
255
期号
1344
页码范围
279-284
出版商
The Royal Society
简介
RNA folding is viewed here as a map assigning secondary structures to sequences. At fixed chain length the number of sequences far exceeds the number of structures. Frequencies of structures are highly non-uniform and follow a generalized form of Zipf’s law: we find relatively few common and many rare ones. By using an algorithm for inverse folding, we show that sequences sharing the same structure are distributed randomly over sequence space. All common structures can be accessed from an arbitrary sequence by a number of mutations much smaller than the chain length. The sequence space is percolated by extensive neutral networks connecting nearest neighbours folding into identical structures. Implications for evolutionary adaptation and for applied molecular evolution are evident: finding a particular structure by mutation and selection is much simpler than expected and, even if catalytic activity …
引用总数
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学术搜索中的文章
P Schuster, W Fontana, PF Stadler, IL Hofacker - Proceedings of the Royal Society of London. Series B …, 1994