作者
Karine Brudey, Jeffrey R Driscoll, Leen Rigouts, Wolfgang M Prodinger, Andrea Gori, Sahal A Al-Hajoj, Caroline Allix, Liselotte Aristimuño, Jyoti Arora, Viesturs Baumanis, Lothar Binder, Patricia Cafrune, Angel Cataldi, Soonfatt Cheong, Roland Diel, Christopher Ellermeier, Jason T Evans, Maryse Fauville-Dufaux, Séverine Ferdinand, Dario Garcia De Viedma, Carlo Garzelli, Lidia Gazzola, Harrison M Gomes, M Cristina Guttierez, Peter M Hawkey, Paul D Van Helden, Gurujaj V Kadival, Barry N Kreiswirth, Kristin Kremer, Milan Kubin, Savita P Kulkarni, Benjamin Liens, Troels Lillebaek, Ho Minh Ly, Carlos Martin, Christian Martin, Igor Mokrousov, Olga Narvskaïa, Yun Fong Ngeow, Ludmilla Naumann, Stefan Niemann, Ida Parwati, Zeaur Rahim, Voahangy Rasolofo-Razanamparany, Tiana Rasolonavalona, M Lucia Rossetti, Sabine Rüsch-Gerdes, Anna Sajduda, Sofia Samper, Igor G Shemyakin, Urvashi B Singh, Akos Somoskovi, Robin A Skuce, Dick Van Soolingen, Elisabeth M Streicher, Philip N Suffys, Enrico Tortoli, Tatjana Tracevska, Véronique Vincent, Tommie C Victor, Robin M Warren, Sook Fan Yap, Khadiza Zaman, Françoise Portaels, Nalin Rastogi, Christophe Sola
发表日期
2006/12
期刊
BMC microbiology
卷号
6
页码范围
1-17
出版商
BioMed Central
简介
Background
The Direct Repeat locus of the Mycobacterium tuberculosis complex (MTC) is a member of the CRISPR (Clustered regularly interspaced short palindromic repeats) sequences family. Spoligotyping is the widely used PCR-based reverse-hybridization blotting technique that assays the genetic diversity of this locus and is useful both for clinical laboratory, molecular epidemiology, evolutionary and population genetics. It is easy, robust, cheap, and produces highly diverse portable numerical results, as the result of the combination of (1) Unique Events Polymorphism (UEP) (2) Insertion-Sequence-mediated genetic recombination. Genetic convergence, although rare, was also previously demonstrated. Three previous international spoligotype databases had partly revealed the global and local geographical structures of MTC bacilli populations, however, there was a need for the …
引用总数
学术搜索中的文章
K Brudey, JR Driscoll, L Rigouts, WM Prodinger, A Gori… - BMC microbiology, 2006