作者
Kristina A Stoermer, Adam Burrack, Lauren Oko, Stephanie A Montgomery, Luke B Borst, Ronald G Gill, Thomas E Morrison
发表日期
2012/10/15
期刊
The Journal of Immunology
卷号
189
期号
8
页码范围
4047-4059
出版商
American Association of Immunologists
简介
Chikungunya virus (CHIKV) and Ross River virus (RRV) cause a debilitating, and often chronic, musculoskeletal inflammatory disease in humans. Macrophages constitute the major inflammatory infiltrates in musculoskeletal tissues during these infections. However, the precise macrophage effector functions that affect the pathogenesis of arthritogenic alphaviruses have not been defined. We hypothesized that the severe damage to musculoskeletal tissues observed in RRV-or CHIKV-infected mice would promote a wound-healing response characterized by M2-like macrophages. Indeed, we found that RRV-and CHIKV-induced musculoskeletal inflammatory lesions, and macrophages present in these lesions, have a unique gene-expression pattern characterized by high expression of arginase 1 and Ym1/Chi3l3 in the absence of FIZZ1/Relmα that is consistent with an M2-like activation phenotype. Strikingly, mice …
学术搜索中的文章
KA Stoermer, A Burrack, L Oko, SA Montgomery… - The Journal of Immunology, 2012