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Should philosophers of science be paying attention to developments in “nanoscience”? Undoubtedly, it is too early to tell for sure. The goal of this paper is to take a preliminary look. In particular, I look at the use of computational models in the study of nano-sized solid-state materials. What I find is that there are features of these models that appear on their face to be at odds with some basic philosophical intuitions about the relationships between different theories and between theories and their models. My conclusion is that developments in nanoscience are not an unlikely place for novel insights in the philosophy of science to emerge.