作者
Hassan Askari, Ehsan Raeis-Abdollahi, Mohammad Foad Abazari, Hassan Akrami, Sina Vakili, Amir Savardashtaki, Amir Tajbakhsh, Nima Sanadgol, Asaad Azarnezhad, Leila Rahmati, Payman Raise Abdullahi, Shohreh Zare Karizi, Ali Reza Safarpour
发表日期
2022/7
来源
Molecular biology reports
卷号
49
期号
7
页码范围
7039-7056
出版商
Springer Netherlands
简介
Background
MicroRNAs (miRNAs) are non-coding, endogenous, single-stranded, small (21–25 nucleotides) RNAs. Various target genes at the post-transcriptional stage are modulated by miRNAs that are involved in the regulation of a variety of biological processes such as embryonic development, differentiation, proliferation, apoptosis, inflammation, and metabolic homeostasis. Abnormal miRNA expression is strongly associated with the pathogenesis of multiple common human diseases including cardiovascular diseases, cancer, hepatitis, and metabolic diseases.
Methods and results
Various signaling pathways including transforming growth factor-β, apoptosis, and Wnt signaling pathways have also been characterized to play an essential role in kidney diseases. Most importantly, miRNA-targeted pharmaceutical manipulation has represented a promising new therapeutic approach against kidney diseases …
学术搜索中的文章
H Askari, E Raeis-Abdollahi, MF Abazari, H Akrami… - Molecular biology reports, 2022