作者
Rama Saha, Hans Järnbert Pettersson, Pia Svedberg, Matts Olovsson, Agneta Bergqvist, Lena Marions, Per Tornvall, Ralf Kuja-Halkola
发表日期
2015/10/1
期刊
Fertility and sterility
卷号
104
期号
4
页码范围
947-952
出版商
Elsevier
简介
Objective
To estimate the relative contribution of genetic influences and prevalence on endometriosis.
Design
Analysis of self-reported data from a nationwide population-based twin registry.
Setting
Not applicable.
Patient(s)
A total of 28,370 women, female monozygotic (MZ) or dizygotic (DZ) twins, who participated in either of two surveys (1998–2002 or 2005–2006).
Intervention(s)
None.
Main Outcome Measure(s)
Self-reported endometriosis, validated by medical records.
Result(s)
A history of endometriosis was reported by 1,228 female twins. The probandwise concordance was 0.21 for MZ and 0.10 for DZ twins. Higher within-pair (tetrachoric) correlation was observed among MZ (0.47) compared with DZ (0.20) twins. The best-fitting model revealed a contribution of 47% by additive genetic factors and the remaining 53% attributed to unique environmental effects.
Conclusion(s)
Our findings suggest both genetic and …
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