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In the present research, the feasibility of using waste glass as replacement for natural river sand was investigated. Glass wastes dumped in landfill pose environmental pollution and research on its reuse in construction industries need to be carried out. An experimental work was performed to study the slump, unit weight, compressive strength, splitting tensile strength, flexural strength, modulus of elasticity, ultrasonic pulse velocity, dry density and chloride ion penetration test at different curing ages at 7, 14 and 28 days of concrete. Investigation on concrete properties with various% of glass powder (0%, 5%, 10%, 15% and 20%) were done on fresh and hardened concrete. The complete stress-strain behaviour, mechanical strength and durability properties of concrete with partial replacement of natural river sand by glass powder were investigated through standard tests. The optimum glass powder content is found out by testing the specimens prepared using different grades of concrete (M20, M30, M40, M50 and M60). All the fresh concrete mixes were tested also for the workability properties by conducting slump cone tests. According to the test results, it is observed that the slump value of fresh concrete increase gradually with% of glass powder upto 40% replacements. The gradual increase in compressive strength, flexural strength and split tensile strength with the addition of waste glass powder upto 30% was observed. The addition of 40% and 50% replacements, the strength values of concrete are comparable with that of the control mix. The density and modulus of elasticity of concrete also gradually increases from 0% to 50% addition of glass …