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Background Infections are a major cause of morbidity and mortality in CLL patients (pts), and COVID-19 pandemic has deeply emphasized the frailty of these patients. The systemic effect on the immune system induced by therapies and the intrinsic disease-related immune dysfunction are the main cornerstones in defining susceptibility to infections. It is well established that hypogammaglobulinemia and IGHV mutational status are factors associated with infection risk in CLL. Despite infection risk-assessment guidelines are available in clinical practice to guide an appropriate infection prophylaxis, to our knowledge an infectious risk assessment score system is not available in CLL to stratify patients.

Aims The aim of this study was to define a simple easy-to-use infectious risk score to facilitate clinical practice stratification of CLL pts, based on Binet stage, hypogammaglobulinemia (HGG), age and IGHV mutational …