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The COVID-19 pandemic has infected over 150,000 million people worldwide, causing approximately 3 million deaths, and a worldwide effort was made to develop efficient vaccines for this disease [1]. The BNT162b2 mRNA COVID-19 vaccine has shown safety and efficacy, conferring 95% protection against COVID-19 in persons 16 years of age or older [2]. According to Italy’s Strategic Plan for anti-SARS-CoV-2/COVID-19 vaccination, BNT162b2 mRNA COVID-19 vaccine has been proposed also for fragile patients [3]. Myelofibrosis (MF) is a clonal chronic myeloproliferative neoplasm (MPN) characterized by bone marrow fibrosis, progressive cytopenia, and extramedullary hematopoiesis. Anemia, infections, and progression to leukemia represent MF complications. MF patients are considered fragile, and thus eligible for COVID-19 vaccination, starting in March 2021, in Italy. According to the International …