作者
José Carlos Machado, Paul Pharoah, Sónia Sousa, Ralph Carvalho, Carla Oliveira, Céu Figueiredo, António Amorim, Raquel Seruca, Carlos Caldas, Fátima Carneiro, Manuel Sobrinho–simões
发表日期
2001/10/1
期刊
Gastroenterology
卷号
121
期号
4
页码范围
823-829
出版商
WB Saunders
简介
Background & Aims
Interleukin (IL)-1 gene cluster proinflammatory polymorphisms have been associated with development of gastric atrophy and with increased risk of gastric carcinoma. We aimed to determine the association between IL-1 loci polymorphisms and increased risk of gastric carcinoma in samples from a Portuguese population, and to find whether there was any relationship with the histologic types of gastric carcinoma.
Methods
In a case-control study including 220 controls and 152 patients with gastric carcinoma (intestinal, 76; diffuse, 37; and atypical, 39), both the IL-1B-511 biallelic polymorphism and the IL-1RN penta-allelic variable number of tandem repeats were genotyped.
Results
We found a significant association between the IL-1 polymorphisms and increased risk for tumor development in patients with intestinal-type gastric carcinoma. A trend towards an increased risk of tumor …
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