查看文章

▪ Objective: To prospectively study the clinical features, pathophysiology, treatment, and prognosis of Wegener granulomatosis.

▪ Design: Of the 180 patients with Wegener granulomatosis referred to the National Institute of Allergy and Infectious Diseases during the past 24 years, 158 have been followed for 6 months to 24 years (a total of 1229 patient-years).

▪ Measurements: Characteristics of clinical presentation, surgical pathology, course of illness, laboratory and radiographic findings, and the results of medical and surgical treatment have been recorded in a computer-based information retrieval system.

▪ Setting: The Warren Magnuson Clinical Center of the National Institutes of Health.

▪ Main Results: Men and women were equally represented; 97% of patients were white, and 85% were more than 19 years of age. The mean period of follow-up was 8 years. One hundred and thirty …