作者
H Mitsumoto, AM Ulug, SL Pullman, CL Gooch, S Chan, M-X Tang, X Mao, AP Hays, AG Floyd, V Battista, J Montes, S Hayes, S Dashnaw, P Kaufmann, PH Gordon, J Hirsch, B Levin, LP Rowland, DC Shungu
发表日期
2007/4/24
期刊
Neurology
卷号
68
期号
17
页码范围
1402-1410
出版商
Lippincott Williams & Wilkins
简介
Objective: To investigate the value of objective biomarkers for upper (UMN) and lower (LMN) motor neuron involvement in ALS.
Methods: We prospectively studied 64 patients with ALS and its subsets using clinical measures, proton MR spectroscopic imaging (1H MRSI), diffusion tensor imaging, transcranial magnetic stimulation, and the motor unit number estimation (MUNE) at baseline and every 3 months for 15 months and compared them with control subjects.
Results: 1H MRSI measures of the primary motor cortex N-acetyl-aspartate (NAA) concentration were markedly reduced in ALS (p = 0.009) and all UMN syndromes combined (ALS, familial ALS [fALS], and primary lateral sclerosis; p = 0.03) vs control values. Central motor conduction time to the tibialis anterior was prolonged in ALS (p < 0.0005) and combined UMN syndromes (p = 0.001). MUNE was lower in ALS (p < 0.0005) and all LMN …
引用总数
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