作者
Xiang Li, Dajiang Zhu, Xi Jiang, Changfeng Jin, Xin Zhang, Lei Guo, Jing Zhang, Xiaoping Hu, Lingjiang Li, Tianming Liu
发表日期
2014/4
期刊
Human brain mapping
卷号
35
期号
4
页码范围
1761-1778
简介
Functional connectomes (FCs) have been recently shown to be powerful in characterizing brain conditions. However, many previous studies assumed temporal stationarity of FCs, while their temporal dynamics are rarely explored. Here, based on the structural connectomes constructed from diffusion tensor imaging data, FCs are derived from resting‐state fMRI (R‐fMRI) data and are then temporally divided into quasi‐stable segments via a sliding time window approach. After integrating and pooling over a large number of those temporally quasi‐stable FC segments from 44 post‐traumatic stress disorder (PTSD) patients and 51 healthy controls, common FC (CFC) patterns are derived via effective dictionary learning and sparse coding algorithms. It is found that there are 16 CFC patterns that are reproducible across healthy controls, and interestingly, two additional CFC patterns with altered connectivity patterns …
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