作者
Oswald D Kothgassner, Marie Pellegrini, Andreas Goreis, Vito Giordano, Joy Edobor, Susanne Fischer, Paul L Plener, Mercedes M Huscsava
发表日期
2021/4/1
来源
Psychoneuroendocrinology
卷号
126
页码范围
105168
出版商
Pergamon
简介
Background
Post-traumatic stress disorder (PTSD) is a debilitating disorder that is often accompanied by alterations in the hypothalamic-pituitary (HPA) axis. While there is abundant evidence for the efficacy of psychological therapies in reducing post-traumatic stress symptoms, barely anything is known about pharmacological interventions. Given the role of the HPA axis in the pathophysiology of PTSD, the aim of this study was to provide the first meta-analysis of Hydrocortisone as a potential treatment for this condition.
Method
A systematic review of randomized-controlled trials (RCTs) was conducted to investigate the efficacy of hydrocortisone in the prevention and curative treatment of post-traumatic stress symptoms. This study was pre-registered with the OSF (doi:10.17605/OSF.IO/GJAZF).
Findings
Eight studies (9 effect sizes) covering 362 participants met our inclusion criteria. We found that Hydrocortisone as …
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