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Study Design.

Human intervertebral disc was obtained for the study of hypoxia inducible factor (HIF)-1α and apoptosis using immunohistochemical staining.

Objective.

To study the expression of HIF-1α and apoptosis in herniated lumbar discs.

Summary of Background Data.

The presence of HIF-1α in human chondrocytes and rat intervertebral discs has been proven; however, to our knowledge, its expression in human intervertebral disc cells has not been reported. Apoptosis of the human intervertebral disc appears as a degenerative change caused by the aging of the intervertebral disc. To our knowledge, there is no reported study showing the correlation between apoptosis and HIF-1α in the human intervertebral disc.

Methods.

There were 15 human intervertebral discs stained for HIF-1α immunohistochemically, and apoptosis was detected using the terminal deoxynucleotidyl transferase mediated-dUTP nick end …