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Background: Some reports suggest that obesity could be a risk factor for complications in coronavirus disease 2019 (COVID-19)(1). Several mechanisms could explain this. First, adipocytes, which activate the inflammatory cascade, can increase risk for thromboembolism and susceptibility to the cytokine storm described in COVID-19 (2). Second, obesity negatively affects lung mechanics, which could predispose obese persons to more severe respiratory distress and failure (3). Finally, obesity can alter mitochondrial bioenergetics in lung epithelial cells and increase risk for acute lung injury (4). However, some have suggested an obesity paradox in some critical illnesses, including acute respiratory distress syndrome, where patients with obesity may have improved outcomes; whether this phenomenon occurs in patients with COVID-19 is unclear (5).

Objective: To study the association between obesity and outcomes …