作者
Colin Birkenbihl, Yasamin Salimi, Daniel Domingo‐Fernández, Holger Fröhlich, Martin Hofmann‐Apitius
发表日期
2020/12
期刊
Alzheimer's & Dementia
卷号
16
页码范围
e043052
简介
Background
Data collected in cohort studies lay the groundwork for a plethora of Alzheimer’s disease (AD) research endeavours. While there exist numerous cohort datasets in our field, few dedicated efforts have focused on comparing these datasets to each other. In recent years, large research consortia, such as EMIF and ROADMAP, were formed to investigate and evaluate the AD data landscape. To the best of our knowledge, such previous approaches have solely investigated cohorts at the metadata level without considering the cohort dataset itself. In this work, we explored eight major AD cohort datasets with the aim of 1) characterizing their underlying data, 2) assessing the quantity and availability of data, 3) evaluating the interoperability across distinct cohort datasets, and 4) presenting our findings in an interactive web application. Thus, we allow researchers to investigate the AD data landscape and find …
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