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For the preterm infant with respiratory insufficiency requiring supplemental oxygen, tight control of oxygen saturation (SpO₂) is advocated, but difficult to achieve in practice. Automated control of oxygen delivery has emerged as a potential solution, with six control algorithms currently embedded in commercially-available respiratory support devices. To date, most clinical evaluations of these algorithms have been short-lived crossover studies, in which a benefit of automated over manual control of oxygen titration has been uniformly noted, along with a reduction in severe SpO₂ deviations and need for manual FiO₂ adjustments. A single non-randomised study has examined the effect of implementation of automated oxygen control with the CLiO₂ algorithm as standard care for preterm infants; no clear benefits in relation to clinical outcomes were noted, although duration of mechanical ventilation was lessened. The …