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Pemphigus represents a group of chronic inflammatory disorders characterized by autoantibodies that target components of desmosomes, leading to the loss of intercellular adhesion between keratinocytes and causing intraepithelial blistering. The pemphigus group consists of four main clinical types with several variants: pemphigus vulgaris (with pemphigus vegetans and pemphigus herpetiformis as variants), pemphigus foliaceus, paraneoplastic pemphigus and IgA pemphigus (with two clinical variants: intraepidermal neutrophilic IgA dermatosis and subcorneal pustular dermatosis). Genetic factors are involved in the pathogenesis, with HLA‑DR4 (DRB1* 0402) and HLA‑DRw6 (DQB1* 0503) allele more common in patients with pemphigus vulgaris, HLA class II DRB1* 0344 and HLA Cw* 1445 correlated with paraneoplastic pemphigus, and HLA‑DRB1* 04: 01, HLA‑DRB1* 04: 06, HLA‑DRB1* 01: 01, HLA‑DRB1 …