作者
Bovine HapMap Consortium, Richard A Gibbs, Jeremy F Taylor, Curtis P Van Tassell, William Barendse, Kellye A Eversole, Clare A Gill, Ronnie D Green, Debora L Hamernik, Steven M Kappes, Sigbjørn Lien, Lakshmi K Matukumalli, John C McEwan, Lynne V Nazareth, Robert D Schnabel, George M Weinstock, David A Wheeler, Paolo Ajmone-Marsan, Paul J Boettcher, Alexandre R Caetano, Jose Fernando Garcia, Olivier Hanotte, Paola Mariani, Loren C Skow, Tad S Sonstegard, John L Williams, Boubacar Diallo, Lemecha Hailemariam, Mario L Martinez, Chris A Morris, Luiz OC Silva, Richard J Spelman, Woudyalew Mulatu, Keyan Zhao, Colette A Abbey, Morris Agaba, Flábio R Araujo, Rowan J Bunch, James Burton, Chiara Gorni, Hanotte Olivier, Blair E Harrison, Bill Luff, Marco A Machado, Joel Mwakaya, Graham Plastow, Warren Sim, Timothy Smith, Merle B Thomas, Alessio Valentini, Paul Williams, James Womack, John A Woolliams, Yue Liu, Xiang Qin, Kim C Worley, Chuan Gao, Huaiyang Jiang, Stephen S Moore, Yanru Ren, Xing-Zhi Song, Carlos D Bustamante, Ryan D Hernandez, Donna M Muzny, Shobha Patil, Anthony San Lucas, Qing Fu, Matthew P Kent, Richard Vega, Aruna Matukumalli, Sean McWilliam, Gert Sclep, Katarzyna Bryc, Jungwoo Choi, Hong Gao, John J Grefenstette, Brenda Murdoch, Alessandra Stella, Rafael Villa-Angulo, Mark Wright, Jan Aerts, Oliver Jann, Riccardo Negrini, Mike E Goddard, Ben J Hayes, Daniel G Bradley, Marcos Barbosa da Silva, Lilian PL Lau, George E Liu, David J Lynn, Francesca Panzitta, Ken G Dodds
发表日期
2009/4/24
期刊
Science
卷号
324
期号
5926
页码范围
528-532
出版商
American Association for the Advancement of Science
简介
The imprints of domestication and breed development on the genomes of livestock likely differ from those of companion animals. A deep draft sequence assembly of shotgun reads from a single Hereford female and comparative sequences sampled from six additional breeds were used to develop probes to interrogate 37,470 single-nucleotide polymorphisms (SNPs) in 497 cattle from 19 geographically and biologically diverse breeds. These data show that cattle have undergone a rapid recent decrease in effective population size from a very large ancestral population, possibly due to bottlenecks associated with domestication, selection, and breed formation. Domestication and artificial selection appear to have left detectable signatures of selection within the cattle genome, yet the current levels of diversity within breeds are at least as great as exists within humans.
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