作者
Daniela Alterio, Barbara Alicja Jereczek-Fossa, Benedetta Franchi, Alberto D’Onofrio, Valeria Piazzi, Elena Rondi, Mario Ciocca, Bianca Gibelli, Enrica Grosso, Nicoletta Tradati, Luigi Mariani, Genoveva Ionela Boboc, Roberto Orecchia
发表日期
2007/1/1
期刊
International Journal of Radiation Oncology* Biology* Physics
卷号
67
期号
1
页码范围
144-150
出版商
Elsevier
简介
Purpose
To evaluate the incidence of thyroid disorders and dose distribution to the thyroid in patients treated with radiotherapy for head-and-neck carcinomas.
Methods and Materials
A retrospective evaluation of data from 73 patients treated for head-and-neck cancers in our department was performed. Thyroid function was evaluated mainly by the measurement of thyrotropin (thyroid stimulating hormone [TSH]). A retrospective analysis of treatment plans was performed for 57 patients. Percentages of thyroid glandular volume absorbing 10, 30, and 50 Gy (V10, V30, and V50 respectively) were considered for statistical analysis.
Results
A majority of patients (61%) had a normal thyroid function whereas 19 patients (26%) had hypothyroidism. Mean thyroid volume was 30.39 cc. Point 3 (located at isthmus) absorbed lower doses compared with other points (p < 0.0001). Median values of V10, V30, and V50 were 92 …
引用总数
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D Alterio, BA Jereczek-Fossa, B Franchi, A D'Onofrio… - International Journal of Radiation Oncology* Biology …, 2007