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Tabernaemontana divaricata (L). R. Br belonging to Apocynaceae family is traditionally used to treat various disorders including neurological problems. In the view of its application in the management of epilepsy, present investigation was carried out to assess the anti-seizure potential of Tabernaemontana divaricata flower methanolic extract (TDFME) against maximal electroshock (MES) and pentylene tetrazole (PTZ) induced convulsions in rats and mice respectively. Two doses of TDFME, 250 & 500 mg/kg were used in the experiments. Phenytoin (PHT) 25 mg/kg, ip and Diazepam (DZP) 4 mg/kg, ip were used as standard anticonvulsant drugs. TDFME at dose of 250 mg/kg, failed to reduce hind limb extensor phase in MES model. However, it significantly delayed onset of both myoclonic spasm and convulsions with p< 0.01 and p< 0.05 respectively. High dose of TDFME (ie 500 mg/kg) significantly (p< 0.05) reduced hind limb extensor phase in MES model, delayed onset of myoclonic spasm & convulsions with significance (p< 0.01) & (p< 0.001) respectively in PTZ model. The incidence of convulsions & percentage mortality observed was 50% less when compared to the control group. Thus, the effect of TDFME (500 mg/kg) was similar to that of DZP in PTZ model. These findings suggest that TDFME possesses anti-seizure activity.